weekly biotechnology news wrap up

February 10, 2016

February 10, 2017

This week’s headlines include: Cellectis gets U.S. go-ahead to test ‘off-the-shelf’ cell therapy, Serono spinout raises €29M for phase 2 Parkinson’s trials, BioTime Acquires Retinal Repair Cell Therapy from UPMC, How the Anti-Vaxxers Are Winning, U.S. FDA approves Bristol-Myers’ Opdivo for bladder cancer, and 13 UC Berkeley faculty members awarded research grants by CZ Biohub,” The Daily Californi


 “Cellectis gets U.S. go-ahead to test ‘off-the-shelf’ cell therapy,” Reuters

“Cellectis has won U.S. regulatory approval to run an early clinical trial using its gene edited cell therapy product UCART123 for blood cancers, boosting the French biotech firm’s ambitions in the hot area of cancer research...”

“Serono spinout raises €29M for phase 2 Parkinson’s trials,” Fierce Biotech

“Prexton Therapeutics has raised €29 million ($31 million) to take its Parkinson’s disease candidate through two phase 2 trials. The Series B positions the Merck Serono spinout to build on last year’s phase 1 success by testing the mGluR4 positive allosteric modulator in larger efficacy studies…”

“BioTime Acquires Retinal Repair Cell Therapy from UPMC,” Genetic Engineering News

“Regenerative medicine company BioTime expanded its ophthalmology portfolio through the acquisition of global rights to the University of Pittsburgh Medical Center’s (UPMC) stem cell-derived retinal repair platform IP. The cell therapy technology, developed in partnership with BioTime, generates 3-D retinal tissue from human pluripotent stem cells for use as implants to repair retinas in patients with advanced retinal degradation. The licensing deal has been made through UPMC’s Innovation Institute…”

“How the Anti-Vaxxers Are Winning,” The New York Times

“It’s looking as if 2017 could become the year when the anti-vaccination movement gains ascendancy in the United States and we begin to see a reversal of several decades in steady public health gains. The first blow will be measles outbreaks in America…”

“U.S. FDA approves Bristol-Myers’ Opdivo for bladder cancer,” Reuters

“The U.S. Food and Drug Administration on Thursday expanded the use of Bristol-Myers Squibb Co’s Opdivo to include treatment of urothelial carcinoma, the most common type of bladder cancer…”

“13 UC Berkeley faculty members awarded research grants by CZ Biohub,” The Daily Californian

“Thirteen UC Berkeley faculty members have been awarded up to $1.5 million in grants each by the Chan Zuckerberg Biohub to carry out biomedical research. CZ Biohub — founded in September 2016 with an investment from Facebook founder and CEO Mark Zuckerberg and his wife, pediatrician Priscilla Chan — is a nonprofit medical research organization dedicated to encouraging and funding research related to finding cures for diseases. The 13 campus faculty are part of a group of 47 investigators chosen by CZ Biohub, who come from Stanford University, UC San Francisco and UC Berkeley, the organization’s partners.”

In Case You Missed It, Recent Articles on Cell Culture Dish and Downstream Column:

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Cell Culture Events:

Bioprocess International West – February 27-March 2, 2017, San Francisco

The BPI West 2017 agenda format is designed to break down silos across multiple departments that work in the same stage of development. With four concurrent tracks focused on early stage process development through commercial manufacturing, attendees can collectively share challenges and discuss the solutions needed to improve the speed, cost and quality of biologics development.

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World Vaccine Congress – April 10-12, 2017, Washington D.C.

The 17th Annual World Vaccine Congress is the place where the global vaccine industry meets to discuss commercial and scientific issues around regulation, strategy, manufacturing, trials, partnering, influenza, cancer, emerging diseases and veterinary vaccines.

Across 150 sessions, you will learn from leading experts across the issues most impacting on the wider vaccine sector, as well as delve into your specialist area of research and job focus in co-located conferences.

Meet over 700 of your peers in one room and take advantage of the multiple extended networking breaks, co-located World Vaccine Congress (including 7 streams on Immune Profiling, Cancer & Immunotherapy, Influenza & Respiratory, Clinical Trials, Emerging Diseases, Partnerships, Veterinary Vaccines and Bioprocessing & Manufacturing) as well as the evening drinks reception.

For more information, please visit the website https://goo.gl/nJ2bZ1


Case Study: Merck Presents Scale Up of Continuous Chromatography using Cadence BioSMB Process System – February 20, 2017

In the present study, the development of a continuous Protein A chromatography process step using KANEKA KanCapA for the capture of a therapeutic mAb is described. The method was developed initially in a batch mode and then transferred to the Cadence BioSMB PD system. This five column process was then successfully scaled-up 150-fold using the Cadence BioSMB Process system. The entire process development and scale-up was completed within four weeks and described in detail along with the process economic benefits of using multi-column chromatography.

Continuous Bioprocessing Solutions: An Update on Significant Enabling Technology Advances – March 7, 2017

While continuous processing has been applied for several decades, the highly regulated biopharm industry has just started to embrace this approach. The team at Pall Life Sciences has leveraged an industry-leading single-use portfolio to deliver innovative continuous bioprocessing solutions to the market. Join our team as they detail the development journey, and highlight critical advances to date.