BIA Separations is the leading developer and manufacturer of CIM® (Convective Interaction Media) monolithic chromatographic columns for production, purification, and analytics of large biomolecules. Our highly skilled team has more than two decades of accumulated knowledge in downstream processing and HPLC analytics. BIA Separations innovations include:
- CIM® Monolith columns developed to resolve stubborn difficulties encountered by traditional particle based chromatography and results in significant valuable improvements in yield, quality and costs in downstream processing of viruses, VLPs, phages, pDNA, and large proteins. CIM monolithic columns are distinguished for their flow independent performance, resulting in fast separation, concentration, purification, removal, and analytics;
- Based on 20 years of experience with over 500 running projects Purification Process Development for clinical phase trials and market supply of AAV (all serotypes), Flu virus (all serotypes), Adeno, Vaccinia/MVA, exosome, pDNA, RNA and many other complex biomolecule based biopharmaceuticals;
- PATfixTM, unique Critical Quality Attributes (CQA) analyser based on HPLC principle combined with CIM®columns and advanced multivariate data analysis algorithms to track host cell impurities in a timely manner.
Our mission is to develop and produce CIM monolithic columns of the highest quality and to provide superior method development services for purification and HPLC analytics of biopharmaceuticals. For more information, please visit www.biaseparations.com.
Monolithic Chromatography Monoliths are unique from other forms of chromatography media for several reasons. Monolith architecture consists of highly interconnected convective channels that are distributed throughout the entire bed. The large channels are easily available for ... Continued