Gold Sponsor
Pall Biotech
Drawing on nearly 70 years of experience supporting cGMP manufacturing of vaccines and protein-based therapeutics, Pall Biotech’s innovative cell therapy platform is designed to help our customers overcome the challenges associated with the production of live cells for therapies. Pall Biotech is dedicated to helping our customers achieve their cell therapy commercialization goals.
Associated Experts
Job Title: Manager, Continuous Bioprocess, Scientific and Laboratory Services Europe
Job Title: Global Product Manager, Chromatography Sorbents & Membranes
Job Title: Senior Global Marketing Manager, Cell & Gene Therapy
Job Title: Senior Marketing Director – Downstream Processing
Job Title: Global Product Manager
Job Title: Global Product Manager Depth Filtration
Associated Content
Viral Filtration Validation Study Design – A Systematic Method for Choosing the Most Appropriate Test Approach
Viral filter validation is important to ensure the removal of viruses under the conditions seen at process scale when using scale-down models. When designing an effective study, there are key components that must be decided ... Continued
Bioburden Control Strategies for Continuous Downstream Processing
Implementing continuous bioprocessing for biomanufacturing has been increasing in interest. As a result, questions have arisen about the implementation of this strategy for downstream processes. Of particular interest is maintaining a high degree of bioburden ... Continued
Innovative Sorbents Enable a Robust and Streamlined Protein Purification Process
Purification has traditionally been slower to innovate mainly due to the difficulty in changing existing downstream processes, the lack of a universal purification process, and the low capacity of mixed mode chromatography sorbents that has limited their use despite their high resolution. To address these issues, Pall® Biotech recently presented a chromatography process which combines KANEKA KanCapA sorbent, Mustang® Q chromatography membrane and CMM HyperCel™ sorbent. This three-step process has been demonstrated to eliminate the need for diafiltration or dilution between chromatography steps....Continued
Optimizing mAb Purification with Highly Selective Mixed-mode Cation Exchange Sorbent
In today’s market, mAbs are produced for several therapeutic applications, yet they are not a homogeneous family of products. Each mAb is unique, based on its isoelectric point, hydrophobicity and ability to aggregate; the contaminant ... Continued
A Guide for Selecting the Correct Filter Integrity Test Instrument
Overview Selecting the right filter integrity test instrument is an important task. An informed, balanced choice will support the seamless integration of the instrument into critical processes and provide trouble-free operation for years to come. The ... Continued
Continuous biomanufacturing – Key drivers for adoption, economic modelling and regulatory considerations
The Medicine Maker recently published a multi-authored eBook on Continuous Biomanufacturing, titled, “The Continuous Way”. The publication includes seven articles covering the topic of continuous biomanufacturing from a variety of angles. I really enjoyed the ... Continued
Inline Diafiltration Closes the Gap for End-to-End Continuous Bioprocessing
Specifically designed to meet the needs of continuous bioprocessing by supporting key diafiltration applications. These applications include: buffer exchange for final drug substance, desalting or buffer exchange before or after column chromatography, and small molecule contaminant removal....Continued
Cell Harvesting – Selecting a technology compatible with cell density and feed turbidity
Silke Bergheim-Pietza, Global Product Manager Depth Filtration, Pall. discusses challenges faced in the cell harvesting step, in particular, selecting the best cell harvesting method based on the cell density and feed turbidity of the process and meeting the demand of increasing cell densities. Download the cell harvesting technology selection guide and use the guide to compare the latest single-use harvesting technologies....Continued
Continuous Biomanufacturing Implementation Now and in The Future
Dr. Peter Levison, Senior Marketing Director – Downstream Processing, Pall Biotech talks about the evolution and benefits of continuous biomanufacturing, what implementation looks like today and what still needs to be realized for full industry adoption....Continued
Validation of Virus Filtration in Continuous Bioprocessing
Adoption of continuous processes certainly seems on the biomanufacturing horizon and this is not surprising considering the benefits of an integrated continuous approach. Demonstrated benefits include operational flexibility and efficiency, product consistency, increased quality assurance, ... Continued
Downstream Bioprocessing Cost Modeling – Looking at Integrated Continuous, Single-use and Stainless Steel Platforms
Process economics are frequently discussed with respect to continuous biomanufacturing implementation. More specifically, are the potential cost benefits worth making a manufacturing change and in which situations are the benefits greatest? At Biotech Week Boston ... Continued
Optimize Downstream Processing with Single-Pass Inline Concentration
Eliminating the recirculation loop by using a unique flow path design and cassettes staged in a serial and parallel configuration, SPTFF is a viable option even for shear-sensitive proteins. Yields are also often higher because of improved product recovery and lower system working and hold-up volumes....Continued
Achieve Integrated and Scalable Continuous Chromatography
Over the last decade, advances in the upstream processing of monoclonal antibodies (mAbs) has resulted in higher bioreactor titers. With increasing titers, the production bottleneck has shifted to downstream processing. Hence, the biopharmaceutical industry has reached a milestone where the need for higher throughput in downstream processing is leading to the adoption of more efficient multi-column continuous (MCC) counter-current chromatography systems which increase overall productivity while significantly reducing consumables cost...Continued
Continuous bioprocessing – moving from theory to reality
Adoption is on the horizon Continuous manufacturing has been established in several processing industries for many years, providing many benefits over batch manufacturing. The feasibility of continuous processing has now been shown for monoclonal antibodies (mAb) ... Continued
A Look at the Current State of Continuous Bioprocessing
Introduction Recently, BioProcess International in conjunction with Pall Life Sciences published an informative supplement titled, “Is Continuous Bioprocessing the Future? ”. The publication contains 12 articles covering various aspects of continuous bioprocessing as well as additional ... Continued
Cadence Single Pass TFF Provides in-line Concentration, Enables Continuous process
The Cadence ILC permits in-process concentrating, which benefits continuous process applications such as perfusion culture methods. Concentration of bioprocess fluids with lower protein titer, such as those generated during perfusion, before multi-column or continuous chromatography enables significant process cost reduction. Continuous processing is also enabled by the easy integration of the Cadence ILC and its ability to couple a variety of processes for overall process integration....Continued
Clarification Using Acoustic Wave Separation Offers Advantages including -Continuous Process Solution
The harvest and clarification of cell culture bioprocess fluids removes cells and cell debris and provides clarified cell culture harvest fluid for downstream purification. The success of the clarification step can greatly impact efficiency and ease of downstream purification....Continued